Karnali was one of the fourteen zones located in the Mid-Western Development Region of Nepal. The headquarters of Karnali Zone was Jumla.
Karnali Zone was one of the poorest and most remote regions of Nepal, not very accessible by road yet. There are airfields in all districts except Kalikot which is connected seasonally by roadways to Jumla Airport.
Karnali Zone was the largest zone of Nepal, with two national parks. Shey Phoksundo National Park Shey Phoksundo (with Phoksundo Lake-- the deepest lake of Nepal), famous for the snow leopard, is Nepal's largest park with an area of 3,555 km2. Rara National Park surrounds Rara Lake -- at 10.2 km2, Nepal's largest lake -- known as the "Pearl of Nepal".
Karnali is the largest province of Nepal with an area of 30,313 km2 (11,704 sq mi), but the population of the province is very low. The population of the province is 1,701,800, which is least in ranking.